Geistlich Nexo-Gide®

The Dual Surfaces found in Geistlich Nexo-Gide® have been shown in pre-clinical and in vitro testing to provide an environment where cells migrate, proliferate, and differentiate, which supports the formation of new tissue.^1–3

• In vitro testing with cells demostrated retention characteristics that support the maintenance of cells in the location desired¹.
• It was demonstrated in pre-clinical testing that the incidence and severity of surrounding tissue attachment was reduced as compared to the surgical control. This may result in decreased post-operative complications.¹
• In vitro testing with cells demonstrated that the Geistlich Nexo-Gide® provides an environment where cells migrate, proliferate and differentiate^1,2.

Elevated MMP activity after tendon injury has been associated with deterioration of the collagen network⁴. Significant increases of MMP-13 were found in patients undergoing rotator cuff repair for full thickness tears⁴ while MMP-1 and -9 were seen to be elevated in tendons of patients which had failed healing of the rotator cuff⁵. Finally, Alfredson et al showed an upregulation of MMP-2 expression in achilles tendinopathy⁶.

Reduction of MMP activity close to the repair site may improve tendon healing⁷. Geistlich Nexo-Gide® is shown to modulate the activity of MMPs related to tendon repair in vitro. Incubation of MMPs 1, 2, 9 and 13  with Geistlich Nexo-Gide® led to a reduction of MMP activity¹.

Conclusion:  Geistlich Nexo-Gide® has demonstrated the ability to modulate MMP activity in vitro¹.  Modulation of MMP activity after rotator cuff repair may reduce pathologic tissue degradation and favorably influence healing after rotator cuff repair⁶.